BPC-157

Authors:

Michalina Józwiak

Findings:

This document is a literature and patent review concerning the multifunctionality and possible medical application of the BPC 157 peptide.

Study Quality Assessment:

Literature and Patent Review

Authors:

Andrea Zemba Čilić, Darko Perović, Igor Filipčić, Jakša Vukojević, Marija Milavić, Nataša Đuran, Petrana Brečić, Predrag Sikirić, Sanja Štrbe, Spomenko Ilić, Sven Seiverth, Zoran Zoričić

Findings:

The review highlights pleiotropic beneficial effects of pentadecapeptide BPC 157 on the central nervous system, based on studies in rats. BPC 157 counteracted stroke-induced brain neuronal damage, memory, locomotion, and coordination disturbances; resolved drug-induced catalepsy and 'positive-like' schizophrenia symptoms; and promoted advanced healing and functional recovery after spinal cord compression. These findings suggest BPC 157 may resolve various central nervous system disturbances.

Participants:

Animal model: rats (also mentions mice in reviewed studies). The reviewed studies primarily utilized rats for investigating stroke, schizophrenia-like symptoms, and spinal cord injury.

Dosage:

Various dosages of BPC 157 are reported in the reviewed studies, depending on the condition and animal model. Examples include: 2 µg/kg, 10 µg/kg, 200 µg/kg, 0.01 mg/kg (equivalent to 10 µg/kg), 10 ng/kg, 1 pg/kg, and 1 ng/kg. Administration routes mentioned are intraperitoneal, intragastric, and per-orally in drinking water (e.g., 0.16 µg/mL, 0.16 ng/mL). For instance, in a spinal cord injury model, a single intraperitoneal injection of BPC 157 (200 or 2 μg/kg) was used. For schizophrenia-like symptoms, 0.01 mg/kg intraperitoneally was mentioned.

Study Quality Assessment:

The provided text is a literature review published in 'Neural Regeneration Research' (Vol 17, No. 3, March 2022). It states 'Peer review: Externally peer reviewed.' and describes a 'Search Strategy and Selecon Criteria' using PubMed and Google Scholar for studies published between 1995 and 2020. The review focuses on studies predominantly conducted on animal models (rats, mice), and the text acknowledges that 'animal models have possible limitations'. Specific experimental methods from the reviewed studies are mentioned, such as 'bilateral clamping of the common carotid arteries-induced stroke', 'L-NG-nitro arginine methyl ester (L-NAME)-and haloperidol-induced catalepsy', and 'rat spinal cord compression'. The license is CC BY-NC-SA 4.0.

All Effects: