Categories & Effectiveness

Brain Health

Brain Antioxidant Shield

7/10

Strong evidence of effectiveness

Acetylcholine Support

5/10

Moderate evidence of effectiveness

Brain Circulation Boost

4/10

Moderate evidence of effectiveness

Neuro-Repair Support

2/10

Limited evidence of effectiveness

Cognition

Memory & Recall

4/10

Moderate evidence of effectiveness

Learning Speed

3/10

Limited evidence of effectiveness

Physical Performance

Blood Sugar Support

6/10

Moderate evidence of effectiveness

Fat Metabolism

5/10

Moderate evidence of effectiveness

Systemic Health

Cholesterol Management

8/10

Strong evidence of effectiveness

Systemic Antioxidant

8/10

Strong evidence of effectiveness

Anti-Inflammatory (Systemic)

7/10

Strong evidence of effectiveness

Liver Protection

7/10

Strong evidence of effectiveness

Dosage & Side Effects

Recommended Dosage

The commonly recommended intake for adults is one to two cloves of fresh garlic per day, or equivalent doses of garlic powder or extracts, often ranging from 300 mg to 1000 mg daily for standardized preparations like garlic powder. While a specific nootropic threshold isn't defined, effects are generally dose-dependent; high doses, such as 5 ml/kg of raw garlic juice which was lethal in animal studies, should be avoided, and it's prudent to discontinue high-dose garlic supplementation 7 to 10 days before surgery due to potential effects on bleeding time. Individuals on anticoagulant medications, those with bleeding disorders, or those preparing for surgery should exercise caution and consult a healthcare professional.

Potential Side Effects

Common mild side effects of garlic consumption primarily include breath and body odor, and some individuals may experience mild gastrointestinal upset, heartburn, or flatulence, especially with raw garlic or on an empty stomach. Severe or rare risks, particularly with high doses or chronic use, can include an increased risk of bleeding due to garlic's antiplatelet properties, and topical application of raw garlic can cause skin irritation, burns, or allergic dermatitis in sensitive individuals. Individuals taking anticoagulant or antiplatelet medications (like warfarin or aspirin), those with bleeding disorders, or those scheduled for surgery face a higher risk of bleeding complications and should use garlic supplements cautiously.

Bioavailability & Half-Life

The absorption and bioavailability of garlic's active compounds vary depending on the preparation; for instance, S-allylcysteine (SAC) found in Aged Garlic Extract (AGE) is stable, odorless, and highly bioavailable, readily absorbed into the bloodstream. In contrast, allicin, formed when raw garlic is crushed, is less stable and quickly decomposes into other sulfur compounds like diallyl disulfide (DADS) and diallyl trisulfide (DATS), which are found in garlic oil. Garlic and its constituents are metabolized in the liver and can influence the activity of cytochrome P450 enzymes, notably CYP2E1 and CYP3A4, which are involved in the metabolism of many drugs. The elimination half-life of specific garlic compounds like SAC or vinyldithiins is not extensively detailed in general reviews, but the long-term administration in studies (months to years) suggests sustained physiological effects with regular intake.

Interactions & Stacks

Garlic is not commonly cited in specific synergistic nootropic stacks, though its general health benefits, such as improved blood flow and antioxidant effects, could theoretically support overall brain function when combined with other cognitive enhancers. Caution is strongly advised when combining garlic with anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin) due to increased bleeding risk, and with certain medications like saquinavir and other HIV protease inhibitors (reduced efficacy), isoniazid (reduced absorption), drugs metabolized by liver enzymes CYP2E1 and CYP3A4 (altered metabolism), antihypertensives (risk of hypotension), antidiabetes drugs (risk of hypoglycemia), tacrolimus, and sofosbuvir. Meta-analyses and user consensus highlight garlic's significant potential for drug interactions, primarily by affecting drug metabolism pathways and potentiating the effects of blood-thinning medications.

Benefits by Use Case

Neuroprotection & Dementia Risk Reduction

Garlic helps mitigate cardiovascular risk factors like high cholesterol and LDL oxidation, which are linked to dementia, and its antioxidant properties protect neurons. Benefits are generally preventative and long-term, with direct cognitive improvement in humans needing more research.

Cardiovascular Health Support

Garlic can improve cardiovascular health by lowering cholesterol, reducing blood pressure, inhibiting platelet aggregation, and improving arterial elasticity. Effects are often observed with consistent use over several weeks to months, but individual results vary.

Systemic Anti-inflammatory Action

Garlic exhibits potent anti-inflammatory effects by modulating cytokine expression and inhibiting pathways like NF-κB, contributing to overall health. These benefits are broad and support various bodily systems, though specific timelines for noticeable effects can vary.

Antioxidant Defense Boost

Garlic enhances the body's antioxidant capacity by scavenging reactive oxygen species and boosting endogenous antioxidant enzymes like SOD and catalase. This protection against oxidative stress is crucial for cellular health, with benefits accumulating over time.

Immune System Modulation

Garlic and its compounds like allicin can enhance immune cell activity and exhibit antimicrobial properties. Regular intake may support immune function, though it's not a substitute for conventional treatments for infections.

Mechanism of Action

Garlic's neuroprotective and health-promoting effects are attributed to its rich array of organosulfur compounds, such as allicin, S-allylcysteine (SAC), diallyl disulfide (DADS), and ajoene. These compounds exert their influence through multiple pathways: they act as potent antioxidants by scavenging reactive oxygen species (ROS) and enhancing endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase. Garlic also exhibits significant anti-inflammatory activity by inhibiting pro-inflammatory signaling pathways like NF-κB and reducing the production of inflammatory cytokines such as IL-1β and TNF-α. In terms of cardiovascular benefits relevant to brain health, garlic can inhibit HMG-CoA reductase (an enzyme in cholesterol synthesis), reduce LDL cholesterol oxidation, decrease platelet aggregation (by inhibiting thromboxane formation and calcium mobilization), and improve endothelial function. Furthermore, some garlic constituents, like those in Aged Garlic Extract (AGE), have demonstrated anti-apoptotic properties in neuronal cells by attenuating caspase-3 activation and protecting against β-amyloid toxicity. Allicin has also been shown in preclinical models to inhibit cholinesterases and modulate neurotransmitter balance, potentially contributing to cognitive effects.

Frequently Asked Questions

Is garlic considered a nootropic?

How long does it take for garlic to show benefits?

Can I take garlic with other nootropics?

Is fresh garlic more effective than garlic supplements?

What are the main drug interactions with garlic?

What is the best way to consume garlic for brain health?

Are there any significant side effects of taking garlic?

Does garlic help with memory?

Summary & Expert Opinion

Garlic and its diverse bioactive compounds, particularly organosulfur constituents like allicin and S-allyl-cysteine, demonstrate substantial evidence for supporting cardiovascular health and possess significant antioxidant and anti-inflammatory properties, which collectively contribute to its neuroprotective potential. Its strengths lie in robust preclinical data for neuroprotection and well-documented cardiovascular benefits that indirectly support brain health by mitigating risk factors for cognitive decline; however, direct evidence for acute cognitive enhancement in healthy humans is less extensive than its protective effects. Individuals seeking natural, long-term support for brain health, cardiovascular wellness, and systemic antioxidant and anti-inflammatory benefits may find garlic a valuable addition to their regimen. Those on blood-thinning medications (e.g., warfarin), certain HIV drugs (like saquinavir or atazanavir), isoniazid, or other medications with known interactions (especially those metabolized by CYP2E1/3A4 enzymes), as well as individuals with garlic allergies or scheduled for surgery, should exercise caution, avoid high doses, and consult their healthcare provider before regular use.

Research Studies

Showing 5 of 11 studies

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease (2022)

anti-inflammatory antioxidant learning improvement +2 more

Authors:

Paola Tedeschi

Findings:

This review summarizes evidence on the therapeutic potential of allicin and Aged Garlic Extract (AGE) for Alzheimer's Disease, highlighting their potent anti-inflammatory, antioxidant, and neuroprotective activities observed in experimental models. The paper discusses their chemical composition, metabolism, bioavailability, and signaling mechanisms, particularly focusing on how allicin and AGE can improve learning and memory.

Participants:

Review of studies using various experimental models, primarily animal models (mice including APP/PS1 double transgenic, C57BL/6, Senescence-Accelerated Mice (SAM), APP-Tg, Tg2576, D-galactose-treated, streptozotocin-induced, Aβ-induced, scopolamine-treated; rats including those with traumatic spinal cord injury, Aβ-induced, LPS-treated) and in vitro cell models (neuronal PC12 cells, undifferentiated PC12 cells, hippocampal slice cultures, rat hippocampal neurons).

Dosage:

The review details various dosages from the summarized experimental studies. For allicin, examples include 10 mg/kg/day via intragastric administration, 180 mg/kg/day in diet, or 2-50 mg/kg via intraperitoneal injection in animal models. For Aged Garlic Extract (AGE) or its components like S-allyl cysteine (SAC), examples include 2% (w/w) AGE in diet, 0.01%-1.0% AGE in cell media/diet, 25-500 mg/kg AGE p.o., 1-100 µM SAC in vitro, or 20-100 mg/kg SAC in animal models, with varying administration routes and durations.

Study Quality Assessment:

This document is a review article summarizing findings from multiple experimental (in vitro cell culture and in vivo animal model) studies. The review itself notes that the summarized studies are derived from cellular or mouse models and that clinical trials concerning these compounds and Alzheimer's Disease are not present, suggesting this evidence needs confirmation in human studies.

All Effects:

anti-inflammatory antioxidant learning improvement memory improvement neuroprotection

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment (2021)

anti-inflammatory antioxidant cholinesterase inhibition +2 more

Authors:

Muhammad Shahid Nadeem

Findings:

This review describes allicin as an antioxidant and neuroprotective agent that ameliorates cognitive impairment in neurodegenerative and neuropsychological disorders. Allicin achieves this by reducing reactive oxygen species (ROS) through NOX enzyme downregulation and promoting antioxidant enzymes, inhibiting neuroinflammation (via TLR4/MyD88/NF-κB, P38, JNK pathways), inhibiting cholinesterases (relevant to Alzheimer's disease), helping balance neurotransmitters (relevant to ASD and ADHD), and protecting neurons in spinal cord injury by promoting Nrf2. The review concludes that while allicin shows promise, further clinical studies are required to establish its therapeutic efficacy.

Participants:

Review of studies. Participants in the reviewed preclinical studies include animal models (Wistar rats, rabbits, mice including Nrf2 knockout and APP/PS1 models) and human cell lines (HUVECs, RPEs, Caco-2, U87-MG cells). Reviewed clinical studies involved newborn infants with thrush, 20 patients with Behcet's disease, 96 patients in a trial for aphthous ulceration, 52 Chinese patients with oral submucous fibrosis, and participants in an ongoing cancer trial and a trial for common cold.

Dosage:

The reviewed literature mentions a low concentration of allicin (0.4 mM) inhibiting platelet aggregation. Allicin's inhibition of telomerase is described as dose-dependent. Specific dosages for neuroprotection or cognitive improvement are not detailed in this review, and the review notes that dose optimization studies are required.

Study Quality Assessment:

The text is a review article. For the studies it reviews, it mentions: primarily preclinical studies (animal models, human cell lines); a few clinical studies including a 'small-scale clinical study involving only 20 patients', a 'randomized double blind placebo trial involving 96 patients', and an ongoing clinical trial from clinicaltrials.gov with 'no results have been yet reported'. The review acknowledges a limitation: 'Human trials and dose optimization studies are required for the establishment of allicin as a neuroprotective agent'.

All Effects:

anti-inflammatory antioxidant cholinesterase inhibition cognitive improvement neuroprotection

Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.) (2019)

anti-inflammatory anticancer antioxidant +2 more

Authors:

Ao Shang

Findings:

Garlic contains diverse bioactive compounds (e.g., allicin, alliin, S-allyl-cysteine) and studies show its constituents exhibit antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardiovascular protective, anticancer, hepatoprotective, digestive system protective, anti-diabetic, anti-obesity, neuroprotective, and renal protective properties. Garlic is a natural source of bioactive sulfur-containing compounds with applications in functional foods or nutraceuticals for disease prevention and management.

Study Quality Assessment:

Review article. Conflict of interest statement: The authors declare no conflict of interest.

All Effects:

anti-inflammatory anticancer antioxidant cardiovascular protection immunomodulatory

Nutritional prevention of cognitive decline and dementia (2018)

cognitive decline diet nutrition +1 more

Authors:

Ligia J Dominguez, Mario Barbagallo

Findings:

Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions, suggesting nutritional approaches to prevent or slow cognitive decline could have a remarkable public health impact.

All Effects:

cognitive decline diet nutrition prevention

Neuroprotective Effects of Garlic A Review (2008)

anti-apoptotic anti-atherogenic antioxidant +2 more

Authors:

BC Mathew, RS Biju

Findings:

This review suggests garlic possesses neuroprotective effects primarily through its interrelated anti-atherogenic, antioxidant, and anti-apoptotic properties. These actions may help reduce the risk of dementia, including Alzheimer's disease and vascular dementia, by mitigating cardiovascular risk factors (like high cholesterol, LDL oxidation, platelet aggregation, hypertension, homocysteinemia) and by protecting neuronal cells against beta-amyloid toxicity, oxidative stress, and apoptosis. Different garlic preparations (e.g., raw garlic, Aged Garlic Extract (AGE), garlic oil, garlic powder) and their bioactive constituents (e.g., S-allyl-cysteine (SAC), allicin, diallyl disulfide (DADS)) are discussed for these beneficial effects.

Participants:

The review covers studies involving human participants (hypercholesterolemic, healthy, atherosclerotic, hypertensive, smoking & non-smoking individuals) and various animal models (rats, rabbits, chickens, swine, mice, Sprague Dawley rats, Wistar rats, Alzheimer's transgenic mice). It also discusses in vitro research using diverse cell lines (e.g., PC12 neuronal cells, human T cells, vero kidney cells, human FL amniotic cells) and tissue preparations (e.g., rat hepatocytes, rat liver microsomes).

Dosage:

The review mentions various dosages across different studies and contexts: In animal studies (mostly rats): raw garlic juice at 5 ml/kg (resulted in death); chronic administration of garlic powder at 50 mg/day (inhibited spermatogenesis); garlic extract at 100–120 mg protein/kg body weight (intraperitoneally injected); diallyl trisulfide (DAT) rich garlic oil supplement at 5 or 50 mg/kg body weight (fed); oral administration of diallyltetrasulfide (DTS) at 40 mg/kg/day; Aged Garlic Extract (AGE) at 500 mg/ml/kg body weight (i.p.). In humans: ingestion of one or two cloves of garlic per day is considered safe; populations consuming ≥300 mg of garlic powder/day for ≥2 years showed attenuation of age-related aortic stiffness. In vitro studies: DTS at 5–50 µg/ml. It is suggested to stop high doses of garlic seven to ten days before surgery.

Study Quality Assessment:

The review analyzes studies with designs including Randomized Controlled Trials (RCTs), double-blind placebo-controlled, and non-placebo-controlled studies. It notes specific sample sizes (e.g., N=11, N=23, N=34, N=46, N=75 in summarized clinical trials) and trial durations (e.g., 14 days, 2 months, 12 weeks, 4 months, 5 months, 6 months, 'at least four weeks'). Numerous specific biochemical and physiological measurement methods are described (e.g., assays for enzyme activities like HMG-CoA reductase, G6PD; LDL oxidation measurement; platelet aggregation tests; histopathology; chromatographic methods; triphenyltetrazolium staining; flow cytometric assessment). Limitations acknowledged include 'inadequate randomization, selection of inappropriate subjects, and the short duration of trials' potentially accounting for inconsistent findings, the stated need for 'further well-designed randomized, larger clinical trials of longer duration using well standardized preparations', and observations that the 'antioxidant effect of garlic in humans is not well studied' and 'antihypertensive effects of garlic...remain controversial'.

All Effects:

anti-apoptotic anti-atherogenic antioxidant dementia risk reduction neuroprotection

Garlic (Allium sativum L.): adverse effects and drug interactions in humans. (2007)

CYP450 metabolism bleeding risk blood pressure effects +2 more

Findings:

Garlic can cause significant drug interactions. It may decrease the effectiveness of saquinavir, atazanavir, and isoniazid by affecting their blood concentration or absorption, and can alter the metabolism of drugs processed by liver enzymes CYP2E1 and CYP3A4. Garlic might also potentiate anticoagulants/antiplatelet drugs (increasing bleeding risk, e.g., with warfarin), antihypertensives (risking hypotension), and antidiabetes drugs (risking hypoglycemia), and interacts with tacrolimus and sofosbuvir.

Participants:

Humans, particularly those taking medications for HIV/AIDS (e.g., saquinavir, atazanavir, other Protease Inhibitors), tuberculosis (isoniazid), conditions requiring anticoagulants/antiplatelet drugs (e.g., warfarin), high blood pressure (antihypertensive drugs), diabetes (antidiabetes drugs), or drugs metabolized by liver enzymes (Cytochrome P450 2E1 or 3A4 substrates), tacrolimus, or sofosbuvir.

All Effects:

CYP450 metabolism bleeding risk blood pressure effects drug interactions pharmacokinetics

A review on the effects of Allium sativum (Garlic)

anti-inflammatory anticancer antioxidant +2 more

Findings:

This review comprehensively covers Allium sativum (garlic) research from the last decade, detailing its traditional uses, phytochemistry (especially sulfur compounds like allicin), and a wide range of pharmacological activities including antioxidant, hypoglycemic, anti-inflammatory, antihyperlipidemic, anticancer, antimicrobial, hepatoprotective, immunomodulatory, and antiviral effects. The review also discusses toxicological aspects and clinical studies, highlighting garlic's potential for treating conditions like cardiovascular diseases, cancer, and diabetes, largely attributed to its organosulfur compounds.

Participants:

Review of studies involving various animal models (e.g., rats, mice, rabbits, fish), human cell lines, and human participants (e.g., prediabetic pregnant women N=49, type 2 diabetic patients N=60, women with rheumatoid arthritis N=70).

Dosage:

The review cites various dosages from different studies: 0.25 mg/kg (ethyl ether extract, diabetic rodents); 100, 300, or 600 mg/kg daily for 2 months (aged garlic extract, diabetic rats); 250 μg/ml (aqueous extract, in vitro); single doses of 300, 2000, or 5000 mg/kg (ethanolic extract, rodent toxicity); 2%, 4%, or 6% dietary powder (sea bass); garlic pills (human T2D, prediabetic women); 1.2 g, 1.6 g, or 2.4 g daily (garlic-curcuma mixture, human T2D-dyslipidemia); 1000 mg daily for 8 weeks (A. sativum supplement, human RA).

Study Quality Assessment:

The document is a review of research from the last decade, published in 'Front Nutr.' It covers in vitro, in vivo, ex vivo studies, clinical trials (some described as randomized, controlled, double-blind, placebo-controlled with sample sizes e.g., N=49, N=70), meta-analyses, and notes adherence to OECD standards for toxicity studies.

All Effects:

anti-inflammatory anticancer antioxidant cardioprotective hypoglycemic

Chemical Constituents and Pharmacological Activities of Garlic ...

anti-inflammatory anticancer antimicrobial +2 more

Findings:

This review comprehensively enumerates the ethnobotanical and pharmacological aspects of Allium sativum (garlic), focusing on research from the last decade. Garlic houses diverse phytochemicals, notably sulfur-containing compounds like allicin, and exhibits established pharmacological activities including antioxidant, hypoglycemic, anti-inflammatory, antihyperlipidemic, anticancer, antimicrobial, hepatoprotective, and immunomodulatory effects. The review discusses its phytochemistry, traditional uses, toxicological aspects, and clinical studies, highlighting its application for various health conditions such as cardiovascular ailments, neoplastic growth, and diabetes.

Participants:

The review covers studies involving *in vitro* models (various cell lines such as HT22, RAW264.7, DLD-1, SGC-7901, MDCK, Vero), animal models (e.g., rats, mice, rabbits, European sea bass), and human clinical trials (e.g., prediabetic pregnant women N=49, type 2 diabetic patients N=60, women with rheumatoid arthritis N=70).

Dosage:

The review cites various dosages from different studies, including: 0.25 mg/kg (ethyl ether extract, diabetic rodents); 100-600 mg/kg daily for 2 months (aged garlic extract, diabetic rats); solitary administration of 300, 2,000, and 5,000 mg/kg (ethanolic extract, rodent toxicity study); 250 μg/ml (aqueous extract, *in vitro* against zearalenone toxicity); 2-6% dietary garlic granules (European sea bass); 1.2, 1.6, and 2.4 g garlic-curcuma mixture (type 2 diabetes-dyslipidemia patients); 1,000 mg of A. sativum daily for 8 weeks (women with RA); 1.5% black garlic extract in diet (rats); IC50 of approximately 64.08 ± 1.09 μg/mL (hexane extract, against HIV-1 RT); EC50 = 0.01 mg/ml (aqueous extract, against influenza A H1N1).

Study Quality Assessment:

This article is a comprehensive literature review of research from the last decade on Allium sativum, aiming to enumerate ethnobotanical and pharmacological aspects, phytochemistry, ethnopharmacology, toxicological aspects, and clinical studies. It cites specific clinical studies with designs like 'double-blind, placebo-controlled, randomized experiment' (N=70 women with RA) and 'triple-blind, randomly selected controlled study' (N=49 mothers with prediabetes). A toxicity study mentioned followed 'OECD standards 423'. The review is an 'open-access article' under a Creative Commons Attribution License (CC BY), notes an NLM disclaimer, indicates a correction has been published, and lists funding sources and a conflict of interest statement.

All Effects:

anti-inflammatory anticancer antimicrobial antioxidant hepatoprotective

Drug-botanical interactions: a review of the laboratory, animal, and human data

drug-botanical interactions metabolism pharmacodynamics +2 more

Findings:

This review summarizes data on the metabolism, transport, and potential interactions of 8 selected botanicals (black cohosh, Echinacea, garlic, Gingko biloba, green tea, kava, milk thistle, and St John's wort). It highlights that these botanicals share metabolic and transport proteins (e.g., CYP, UGTs, Pgp) with conventional medicines, increasing the likelihood of drug-botanical interactions, and aims to demonstrate how to interpret studies to predict such interactions.

Participants:

Review of studies involving laboratory, animal, and human data. Mentions individuals with cancer as common users of botanicals.

Study Quality Assessment:

Review of laboratory, animal, and clinical studies. Describes common models used to study drug metabolism.

All Effects:

drug-botanical interactions metabolism pharmacodynamics pharmacokinetics transport

Neuroprotective Effects of Aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by b-Amyloid in Rats

cognitive dysfunction neuroinflammation reduction neuroprotection +1 more

Findings:

Aged Garlic Extract (AGE) at doses of 250 and 500 mg/kg BW significantly improved short-term recognition memory in cognitively impaired rats induced by β-Amyloid. AGE also significantly minimized the inflammatory response by reducing the activation of microglia and IL-1β to control levels, similar to Celebrex-treated rats. AGE may be useful for improving short-term recognition memory and relieving neuroinflammation in Aβ-induced rats.

Participants:

Animal model: Adult male Wistar rats

Dosage:

AGE (125, 250, and 500 mg/kg BW, body weight), orally administered, daily for 56 days.

Study Quality Assessment:

Study involved oral administration of Aged Garlic Extract (AGE) daily for 56 days, followed by injection of aggregated Aβ (1-42) into lateral ventricles. Recognition memory evaluated using a novel object recognition (NOR) test. Post-mortem investigation of microglia cells, IL-1β and TNFα in the cerebral cortex and hippocampus. Conflict of interest statement: 'The authors declare no conflict of interest.'

All Effects:

cognitive dysfunction neuroinflammation reduction neuroprotection short-term recognition memory

The effect and underlying mechanisms of garlic extract against cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis of experimental animal studies

We value your privacy

Categories & Effectiveness

Brain Health

Brain Antioxidant Shield

Acetylcholine Support

Brain Circulation Boost

Neuro-Repair Support

Cognition

Memory & Recall

Learning Speed

Physical Performance

Blood Sugar Support

Fat Metabolism

Systemic Health

Cholesterol Management

Systemic Antioxidant

Anti-Inflammatory (Systemic)

Liver Protection

Dosage & Side Effects

Recommended Dosage

Potential Side Effects

Bioavailability & Half-Life

Interactions & Stacks

Benefits by Use Case

Neuroprotection & Dementia Risk Reduction

Cardiovascular Health Support

Systemic Anti-inflammatory Action

Antioxidant Defense Boost

Immune System Modulation

Mechanism of Action

Frequently Asked Questions

Summary & Expert Opinion

Research Studies

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease (2022)

Authors:

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment (2021)

Authors:

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.) (2019)

Authors:

Findings:

Study Quality Assessment:

All Effects:

Nutritional prevention of cognitive decline and dementia (2018)

Authors:

Findings:

All Effects:

Neuroprotective Effects of Garlic A Review (2008)

Authors:

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Garlic (Allium sativum L.): adverse effects and drug interactions in humans. (2007)

Findings:

Participants:

All Effects:

A review on the effects of Allium sativum (Garlic)

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Chemical Constituents and Pharmacological Activities of Garlic ...

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Drug-botanical interactions: a review of the laboratory, animal, and human data