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Nutropica
Semax supplement image

Semax

Last updated: May 4, 2025

Semax is a peptide that has been studied for its effects within the brain. It is investigated for its influence on biological processes, particularly how it interacts with gene expression related to the body's immune and vascular systems, especially under conditions like reduced blood flow. Research, such as studies in animal models, suggests Semax can modulate genetic activity involved in the brain's response to challenges like focal ischemia.

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Categories & Effectiveness

Systemic Health

Immune System Balance

2/10

Limited evidence of effectiveness

Vascular Health

2/10

Limited evidence of effectiveness

Benefits by Use Case

Post-Ischemia Gene Modulation

May influence the expression of genes involved in immune and vascular responses following brain ischemia, based on animal studies. Relevance to human cognitive enhancement is not established.

Neuroprotection Research

Investigated for potential protective effects by modulating genetic pathways in response to brain injury models. Human data and cognitive benefits are currently limited.

Mechanism of Action

Semax appears to exert its effects by influencing gene expression within the brain. Specifically, research indicates it can alter the activity levels of genes associated with the immune system and the vascular system. This modulation has been observed in animal models experiencing focal brain ischemia, suggesting Semax may impact the brain's genetic response pathways during or after such events.

Summary & Expert Opinion

Semax is a peptide primarily studied for its ability to modulate gene expression related to immune and vascular functions in the brain, particularly in animal models of ischemia. Its main strength lies in research exploring molecular mechanisms underlying brain responses to injury. However, its limitations include a lack of broad human data, especially concerning cognitive enhancement, with current evidence largely confined to specific animal research contexts.

Research Studies

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis (2014)

focal ischemia gene expression immune system +1 more
Source

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