Ipamorelin

Description

Ipamorelin is a synthetic peptide known for stimulating the release of growth hormone (GH). It's often explored for potential benefits in muscle growth, fat loss, and anti-aging. This article provides a comprehensive yet accessible overview of Ipamorelin, covering its benefits, dosage, side effects, and more.

Quick Overview: Ipamorelin At-a-Glance

Ipamorelin is a growth hormone releasing peptide (GHRP) that selectively stimulates GH release without significantly impacting cortisol or prolactin levels. Key Benefit(s): May enhance muscle growth, promote fat loss, and improve recovery. Primary Mechanism: Binds to ghrelin receptors in the pituitary gland, stimulating GH release. Best For: Individuals seeking potential benefits in muscle development, fat reduction, and overall well-being. Typical Dose Range: 200-500 mcg per day, split into multiple doses. Key Caution/Consideration: Consult with a healthcare professional before use.

Categories & Effectiveness
Dosage & Side Effects
Benefits by Use Case
Mechanism of Action
Frequently Asked Questions
Summary & Expert Opinion
Research Studies

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Categories & Effectiveness

Mood & Stress

Wellbeing Boost

3/10

Limited evidence of effectiveness

Physical Performance

Strength & Power

5/10

Moderate evidence of effectiveness

Muscle Growth

4/10

Moderate evidence of effectiveness

Muscle Soreness Relief

3/10

Limited evidence of effectiveness

Exercise Recovery

2/10

Limited evidence of effectiveness

Systemic Health

Cellular Repair

4/10

Moderate evidence of effectiveness

Cellular Anti-Aging

3/10

Limited evidence of effectiveness

Dosage & Side Effects

Recommended Dosage

Dosage for Ipamorelin typically ranges from 200-500 mcg per day, often split into multiple doses. For anti-aging or general wellness, some users report success with 200-300 mcg daily. Those targeting muscle growth and fat loss might use 300-500 mcg per day, divided into morning and evening administrations. Pro Tip: Injection sites should be rotated (abdomen, thigh, upper arm) to minimize localized reactions.

Potential Side Effects

Ipamorelin is generally considered to have a mild side effect profile. Common side effects may include injection site reactions such as redness or swelling. Some users have reported headaches, dizziness, or slight nausea, which are usually temporary. Use cautiously if you have a history of insulin resistance, as Ipamorelin may affect glucose metabolism.

Bioavailability & Half-Life

Ipamorelin has a relatively short half-life, typically ranging from 1.5 to 2.5 hours. This means it is quickly cleared from the body, requiring multiple daily administrations to maintain consistent levels. While its bioavailability hasn't been extensively studied, it is administered via subcutaneous injection to bypass first-pass metabolism and ensure absorption. Understanding its short half-life is crucial for optimizing dosing strategies.

Interactions & Stacks

Ipamorelin is sometimes stacked with other peptides to enhance its effects. Combining Ipamorelin with Sermorelin may lead to synergistic benefits, potentially increasing lean muscle mass, improving recovery, and promoting fat loss. Another common stack involves CJC-1295, which can enhance muscle building and fat loss due to its longer half-life and sustained GH release. Consult with a healthcare professional before combining Ipamorelin with other substances.

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Benefits by Use Case

Enhanced Muscle Growth

Ipamorelin stimulates growth hormone release, which can promote protein synthesis and muscle hypertrophy. It may be particularly beneficial for individuals looking to increase lean body mass and improve muscle recovery after exercise.

Improved Fat Loss

By increasing growth hormone levels, Ipamorelin can help accelerate metabolism and promote lipolysis, leading to a reduction in body fat percentage. It may be helpful for individuals seeking to improve body composition and reduce visceral fat.

Mechanism of Action

Ipamorelin is a selective growth hormone secretagogue (GHS). It mimics the action of ghrelin, a naturally occurring hormone, by binding to the ghrelin receptor (GHSR-1a) in the pituitary gland. In simple terms, Ipamorelin stimulates the pituitary gland to release growth hormone, without significantly affecting other hormones like cortisol. This selective action may contribute to its relatively mild side effect profile.

Frequently Asked Questions

What is Ipamorelin?

How is Ipamorelin administered?

What are the potential benefits of Ipamorelin?

What are the common side effects of Ipamorelin?

Is Ipamorelin legal?

Should I consult a doctor before using Ipamorelin?

Where to Buy Ipamorelin

Based on quality, price, and customer reviews, here are our top recommended Ipamorelin supplements:

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Summary & Expert Opinion

For general users, Ipamorelin offers a potentially safer alternative to other GHRPs due to its selective action and reduced side effects. It may aid in muscle growth, fat loss, and recovery when combined with proper diet and exercise. However, consulting a healthcare professional is crucial, as individual responses can vary, and long-term effects are still being studied.

Diving deeper, Ipamorelin's selectivity stems from its unique binding affinity to the GHSR-1a receptor. Unlike some other GHRPs, it exhibits minimal impact on cortisol and prolactin levels, reducing the risk of related side effects. Its action primarily revolves around stimulating the release of GH from somatotroph cells in the anterior pituitary. The released GH then acts on various tissues, stimulating the production of Insulin-like Growth Factor 1 (IGF-1) in the liver, which mediates many of the anabolic effects attributed to GH.

The short half-life of Ipamorelin (1.5-2.5 hours) necessitates multiple daily administrations to maintain elevated GH levels. This pulsatile GH release mimics the natural physiological pattern, potentially minimizing receptor desensitization. However, the lack of extensive human studies warrants caution. While anecdotal evidence suggests benefits in muscle growth, fat loss, and anti-aging, more rigorous clinical trials are needed to fully validate these claims.

Furthermore, while Ipamorelin is generally considered safe, potential long-term effects on glucose metabolism and insulin sensitivity should be monitored, especially in individuals with pre-existing metabolic conditions. Given its influence on GH and IGF-1, there are also theoretical concerns about potential effects on cancer cell proliferation, although current evidence is limited. Therefore, a thorough risk-benefit assessment with a qualified healthcare provider is essential before considering Ipamorelin therapy.

Research Studies

Showing 5 of 7 studies

Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults: Results of a Controlled Trial (2012)

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

anti-nociception attenuation of somatic allodynia attenuation of visceral hypersensitivity +1 more

Findings:

Ghrelin mimetics HM01 (globally active) and ipamorelin (peripherally restricted) significantly attenuated colonic hypersensitivity and somatic allodynia in a rat model of non-inflammatory visceral hypersensitivity. These anti-nociceptive effects were blocked by a ghrelin receptor antagonist, indicating ghrelin receptor-mediated mechanisms are involved. The findings suggest a potential novel approach for treating acute visceral and somatic pain using ghrelin mimetics.

Participants:

Animal model: rats

Dosage:

HM01 administered orally (p.o.) at doses of 1, 3, 10, 30 mg/kg. Ipamorelin (IPAM) administered intravenously (i.v.) at doses of 0.01, 0.1, 1.0 mg/kg. The ghrelin receptor antagonist H0900 was administered orally.

Study Quality Assessment:

Experimental model in rats. Visceral hypersensitivity induced by dilute acetic acid (0.6%) infusion in the colon. Colonic sensitivity assessed via visceromotor behavioral response (VMR) to colorectal distension (CRD). Somatic mechanical allodynia quantified by paw withdrawals to von Frey filament. Compared to vehicle controls. Sample size n=4-6/group for HM01 and ipamorelin experiments. Conflict of interest statement provided: one author reports grants from Helsinn Pharma; two other authors report past or current employment/consultancy with Helsinn entities.

All Effects:

anti-nociception attenuation of somatic allodynia attenuation of visceral hypersensitivity pain treatment

Ipamorelin Therapy for Improving Lean Body Mass in Elderly Patients

growth hormone release lean body mass muscle strength

Findings:

Ipamorelin is effective in stimulating growth hormone release in adults with GHD and has potential benefits for improving lean body mass and muscle strength in elderly patients.

Participants:

adults with GHD, elderly patients

Study Quality Assessment:

Studied in clinical trials and case studies.

Ipamorelin, the First Selective Growth Hormone Secretagogue

drug development growth hormone secretagogue pharmacology

Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy

IGF-I concentrations cardiac function clinical status +1 more

Authors:

Osterziel, K. J. et al.

Findings:

Treatment with recombinant human growth hormone (rhGH) significantly increased left-ventricular mass in patients with dilated cardiomyopathy compared to placebo. However, this was not accompanied by improvements in left-ventricular systolic wall stress, mean blood pressure, systemic vascular resistance, New York Heart Association functional class, left-ventricular ejection fraction, or 6 min walking test distance. Changes in left-ventricular mass were significantly related to changes in serum insulin-like growth factor (IGF)-I concentrations.

Participants:

50 patients (43 men) with chronic heart failure due to dilated cardiomyopathy.

Dosage:

Subcutaneous rhGH (2 IU daily) or placebo for a minimum of 12 weeks.

Study Quality Assessment:

Randomised, double-blind, placebo-controlled study. N=50 patients. Data were analysed by intention to treat.

All Effects:

IGF-I concentrations cardiac function clinical status left-ventricular mass

The GH Secretagogues Ipamorelin and GH-releasing Peptide-6 Increase Bone Mineral Content in Adult Female Rats

GH-releasing peptide-6 bone mineral content bone remodelling +1 more

Findings:

The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. Growth hormone (GH) is of importance for normal bone remodelling.

Participants:

adult female rats

All Effects:

GH-releasing peptide-6 bone mineral content bone remodelling Ipamorelin

The Growth Hormone Secretagogue Ipamorelin Counteracts Glucocorticoid-induced Decrease in Bone Formation of Adult Rats

Ipamorelin bone formation glucocorticoid effects +1 more

Findings:

In adult rats, the growth hormone secretagogue (GHS) Ipamorelin, when administered in combination with glucocorticoids (GC), significantly increased maximum tetanic tension of calf muscles and increased periosteal bone formation rate four-fold compared to GC alone. The study concludes that Ipamorelin counteracted the GC-induced decrease in muscle strength and bone formation.

Participants:

Animal model: 8-month-old female rats

Dosage:

GC (methylprednisolone) 9 mg/kg/day; GHS (Ipamorelin) 100 microg/kg three times daily; or both GC and GHS in combination.

Study Quality Assessment:

In vivo study in an adult rat model. Rats were injected subcutaneously for 3 months. Maximum tetanic tension of calf muscles determined in vivo in a materials testing machine.

All Effects:

Ipamorelin bone formation glucocorticoid effects muscle strength

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Boost your experience

Categories & Effectiveness

Mood & Stress

Wellbeing Boost

Physical Performance

Strength & Power

Muscle Growth

Muscle Soreness Relief

Exercise Recovery

Systemic Health

Cellular Repair

Cellular Anti-Aging

Dosage & Side Effects

Recommended Dosage

Potential Side Effects

Bioavailability & Half-Life

Interactions & Stacks

Recommended Products

Schwarzkümmelöl Kapseln BIO 180 Stück vegane Kapseln I ägyptisch - naturbelassen - kaltgepresst | 1000 mg pro Tagesdosis - bioKontor

Vitamin C mit Zink Tabletten - 1000mg - 6 Monate Vorrat - Für Immunsystem, Energie, Knochen, Haut & Stoffwechsel (EFSA) - 180 vegane Tabletten - Alternative zu Kapseln & Pulver - Vit C von WeightWorld

sanotact Eisen + C Depot, 90 Tabletten, Eisentabletten mit Vitamin C, Nahrungsergänzungsmittel, vegan, 1x täglich, 3 Monats-Vorrat

Benefits by Use Case

Enhanced Muscle Growth

Improved Fat Loss

Mechanism of Action

Frequently Asked Questions

Where to Buy Ipamorelin

Immunsystem-Komplex - 500mg Echinacea mit Vitamin C Zink Selen L-Histidin & Kalmegh - Immunsystem stärken * vegan & ohne Zusätze - 120 Echinacea Purpurea Kapseln für 60 Tage

Cholin Kapseln - 714mg pro Portion - Leberfunktion, Homocystein & Fettstoffwechsel (EFSA) - 180 vegane Kapseln für 3 Monate Vorrat - Cholin Bitartrat von WeightWorld

Vitamin C mit Zink Tabletten - 1000mg - 6 Monate Vorrat - Für Immunsystem, Energie, Knochen, Haut & Stoffwechsel (EFSA) - 180 vegane Tabletten - Alternative zu Kapseln & Pulver - Vit C von WeightWorld

Summary & Expert Opinion

Research Studies

Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults: Results of a Controlled Trial (2012)

Participants:

Study Quality Assessment:

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

Ipamorelin Therapy for Improving Lean Body Mass in Elderly Patients

Findings:

Participants:

Study Quality Assessment:

Ipamorelin, the First Selective Growth Hormone Secretagogue

Findings:

Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy

Authors:

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

The GH Secretagogues Ipamorelin and GH-releasing Peptide-6 Increase Bone Mineral Content in Adult Female Rats

Findings:

Participants:

All Effects:

The Growth Hormone Secretagogue Ipamorelin Counteracts Glucocorticoid-induced Decrease in Bone Formation of Adult Rats

Findings:

Participants:

Dosage:

Study Quality Assessment:

All Effects:

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